# name
Mapping geographical inequalities in childhood diarrhoeal
                morbidity and mortality in low-income and middle-income
                countries, 2000-17: analysis for the Global Burden of Disease
                Study 2017.

# metadata.dc.contributor.author[].value
Disease Diarrhoea Collaborators Local Burden

# metadata.dc.description.abstract[].value
BACKGROUND content: Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea  incidence and mortality is attributable to interventions that
                protect children, prevent infection, and treat disease.
                Identifying subnational regions with the highest burden and
                mapping associated risk factors can aid in reducing preventable
                childhood diarrhoea. - Label: METHODS content: "We used Bayesian
                model-based geostatistics and a geolocated dataset comprising
                15\xE2\x80\x88072\xE2\x80\x88746 children younger than 5 years
                from 466 surveys in 94 LMICs, in combination with findings of
                the Global Burden of Diseases, Injuries, and Risk Factors Study
                (GBD) 2017, to estimate posterior distributions of diarrhoea
                prevalence, incidence, and mortality from 2000 to 2017. From
                these data, we estimated the burden of diarrhoea at varying
                subnational levels (termed units) by spatially aggregating
                draws, and we investigated the drivers of subnational patterns
                by creating aggregated risk factor estimates." - Label: FINDINGS
                content: "The greatest declines in diarrhoeal mortality were
                seen in south and southeast Asia and South America, where
                54\xC2\xB70% (95% uncertainty interval [UI]
                38\xC2\xB71-65\xC2\xB78), 17\xC2\xB74% (7\xC2\xB77-28\xC2\xB74),
                and 59\xC2\xB75% (34\xC2\xB72-86\xC2\xB79) of units,
                respectively, recorded decreases in deaths from diarrhoea
                greater than 10%. Although children in much of Africa remain at
                high risk of death due to diarrhoea, regions with the most
                deaths were outside Africa, with the highest mortality units
                located in Pakistan. Indonesia showed the greatest
                within-country geographical inequality; some regions had
                mortality rates nearly four times the average country rate.
                Reductions in mortality were correlated to improvements in
                water, sanitation, and hygiene (WASH) or reductions in child
                growth failure (CGF). Similarly, most high-risk areas had poor
                WASH, high CGF, or low oral rehydration therapy coverage." -
                Label: INTERPRETATION content: By co-analysing geospatial trends
                in diarrhoeal burden and its key risk factors, we could assess
                candidate drivers of subnational death reduction. Further, by
                doing a counterfactual analysis of the remaining disease burden
                using key risk factors, we identified potential intervention
                strategies for vulnerable populations. In view of the demands
                for limited resources in LMICs, accurately quantifying the
                burden of diarrhoea and its drivers is important for precision
                public health. - Label: FUNDING content: Bill & Melinda
                Gates Foundation.

# metadata.dc.rights[].value
cc by (c) Disease Diarrhoea Collaborators Local Burden, 2020

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Mapping geographical inequalities in childhood diarrhoeal
                morbidity and mortality in low-income and middle-income
                countries, 2000-17: analysis for the Global Burden of Disease
                Study 2017.