# name
HIV-1 DNA predicts disease progression and post-treatment virological control

# metadata.dc.description.abstract[].value
In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials.

# metadata.dc.rights[].value
cc-by (c) Williams, James P. et al., 2014

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
HIV-1 DNA predicts disease progression and post-treatment virological control