# name
Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects

# metadata.dc.description.abstract[].value
Non-steroidal anti-inflammatory drugs (NSAIDs) express anti-tumoral activity mainly  by blocking cyclooxygenase-2 involved in the synthesis of prostaglandins. Therefore, in the last  few decades, many have attempted to explore the possibilities of applying this group of drugs as  effective agents for the inhibition of neoplastic processes. This review summarizes the evidence  presented in the literature regarding the anti-tumoral actions of NSAIDs used as monotherapies as  well as in combination with conventional chemotherapeutics and natural products. In several clinical  trials, it was proven that combinations of NSAIDs and chemotherapeutic drugs (CTDs) were able  to obtain suitable results. The combination with phospholipids may resolve the adverse effects of  NSAIDs and deliver derivatives with increased antitumor activity, whereas hybrids with terpenoids  exhibit superior activity against their parent drugs or physical mixtures. Therefore, the application of  NSAIDs in cancer therapy seems to be still an open chapter and requires deep and careful evaluation.  The literature’s data indicate the possibilities of re-purposing anti-inflammatory drugs currently  approved for cancer treatments

# metadata.dc.rights[].value
cc-by (c) Thiruchenthooran, Vaikunthavasan et al, 2023

# metadata.dc.source[].value
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

# metadata.dc.title[].value
Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects