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Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases

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Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of themost eﬀective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative eﬀects potentially beneficial for diseases with excessive cell turnover. However, RLZ possesses low water solubility and high light- sensibility. We present here optimized NLCs loaded with RLZ (RLZ-NLCs) as a potential topical treatment. RLZ-NLCs were prepared by the hot-pressure homogenization method using active essential oils as liquid lipids, and optimized using the design of experiments approach. RLZ-NLCs were developed obtaining optimal properties for dermal application (mean size below 200 nm, negative surface charge and high RLZ entrapment eﬃcacy). In vitro release study demonstrates that RLZ-NLCs allow the successful delivery of RLZ in a sustained manner. Moreover, RLZ-NLCs are not angiogenic and are able to inhibit keratinocyte cell proliferation. Hence, a NLCs delivery system loading RLZ in combination with natural essential oils constitutes a promising strategy against keratinocyte hyperproliferative conditions.

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International Journal of Molecular Sciences, 2023, vol. 24, p. 8053

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

# metadata.dc.title[].value
Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases