# name
Reaching for the Holy Grail: insights from infection/cure models
                on the prospects for vaccines for Trypanosoma cruzi infection

# metadata.dc.description.abstract[].value
Prevention of Trypanosoma cruzi infection in mammals likely
                depends on either prevention of the invading trypomastigotes
                from infecting host cells or the rapid recognition and killing
                of the newly infected cells by T. cruzi-specific T cells. We
                show here that multiple rounds of infection and cure (by drug
                therapy) fails to protect mice from reinfection, despite the
                generation of potent T cell responses. This disappointing result
                is similar to that obtained with many other vaccine protocols
                used in attempts to protect animals from T. cruzi infection. We
                have previously shown that immune recognition of T. cruzi
                infection is significantly delayed both at the systemic level
                and at the level of the infected host cell. The systemic delay
                appears to be the result of a stealth infection process that
                fails to trigger substantial innate recognition mechanisms while
                the delay at the cellular level is related to the
                immunodominance of highly variable gene family proteins, in
                particular those of the trans-sialidase family. Here we discuss
                how these previous studies and the new findings herein impact
                our thoughts on the potential of prophylactic vaccination to
                serve a productive role in the prevention of T. cruzi infection
                and Chagas disease.

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Versió postprint del document publicat a:
                http://dx.doi.org/10.1590/0074-02760140440

# metadata.dc.relation.ispartof[].value
Memorias do Instituto Oswaldo Cruz, 2015, vol. 110, num. 3, p.
                445-451

# metadata.dc.rights[].value
cc by-nc (c) Instituto Oswaldo Cruz, 2015

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Reaching for the Holy Grail: insights from infection/cure models
                on the prospects for vaccines for Trypanosoma cruzi infection