# name
Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.

# metadata.dc.description.abstract[].value
--- - Label: BACKGROUND NlmCategory: BACKGROUND content: The presence of Plasmodium vivax malaria parasites in the human bone                marrow (BM) is still controversial. However, recent data from a              clinical case and experimental infections in splenectomized
                nonhuman primates unequivocally demonstrated the presence of
                parasites in this tissue. - Label: METHODS NlmCategory: METHODS
                content: In the current study, we analyzed BM aspirates of 7
                patients during the acute attack and 42 days after drug
                treatment. RNA extracted from CD71+ cell suspensions was used
                for sequencing and transcriptomic analysis. - Label: RESULTS
                NlmCategory: RESULTS content: We demonstrated the presence of
                parasites in all patients during acute infections. To provide
                further insights, we purified CD71+ BM cells and demonstrated
                dyserythropoiesis and inefficient erythropoiesis in all
                patients. In addition, RNA sequencing from 3 patients showed
                that genes related to erythroid maturation were down-regulated
                during acute infections, whereas immune response genes were
                up-regulated. - Label: CONCLUSIONS NlmCategory: CONCLUSIONS
                content: This study thus shows that during P. vivax infections,
                parasites are always present in the BM and that such infections
                induced dyserythropoiesis and ineffective erythropoiesis.
                Moreover, infections induce transcriptional changes associated
                with such altered erythropoietic response, thus highlighting the
                importance of this hidden niche during natural infections.

# metadata.dc.rights[].value
cc by-nc-nd (c) Brito, Marcelo A. M. et al, 2020

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Morphological and Transcriptional Changes in Human Bone Marrow During Natural Plasmodium vivax Malaria Infections.