# name
The Strongyloides stercoralis-hookworms association as a path
                to the estimation of the global burden of strongyloidiasis: A
                systematic review

# metadata.dc.description.abstract[].value
Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limi- tations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) “Community”, with surveys including all age groups, and 2) “SAC”, with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hook- worms was identified. Spearman’s coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324–449 million) people, including 22 million (95%CI 20–24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2020, vol. 14, num. 4, p. e0008184

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
The Strongyloides stercoralis-hookworms association as a path
                to the estimation of the global burden of strongyloidiasis: A
                systematic review