# name
Micelle carriers based on dendritic macromolecules containing
                bis-MPA and glycine for antimalarial drug delivery

# metadata.dc.description.abstract[].value
Biomaterials for antimalarial drug transport still need
                to be investigated in order to attain nanocarriers that can
                tackle essential issues related to malaria treatment, e.g.
                complying with size requirements and targeting specificity for
                their entry into Plasmodium-infected red blood cells (pRBCs),
                and limiting premature drug elimination or drug resistance
                evolution. Two types of dendritic macromolecule that can form
                vehicles suitable for antimalarial drug transport are herein
                explored. A new hybrid dendritic-linear-dendritic block
                copolymer based on Pluronic\xC2\xAE F127 and amino terminated
                2,2'-bis(glycyloxymethyl)propionic acid dendrons with a
                poly(ester amide) skeleton (HDLDBC-bGMPA) and an amino
                terminated dendronized hyperbranched polymer with a polyester
                skeleton derived from 2,2'-bis(hydroxymethyl)propionic acid
                (DHP-bMPA) have provided self-assembled and unimolecular
                micelles. Both types of micelle carrier are biocompatible and
                exhibit appropriate sizes to enter into pRBCs. Targeting studies
                have revealed different behaviors for each nanocarrier that may
                open new perspectives for antimalarial therapeutic approaches.
                Whereas DHP-bMPA exhibits a clear targeting specificity for
                pRBCs, HDLDBC-bGMPA is incorporated by all erythrocytes. It has
                also been observed that DHP-bMPA and HDLDBC-bGMPA incorporate
                into human umbilical vein endothelial cells with different
                subcellular localization, i.e. cytosolic and nuclear,
                respectively. Drug loading capacity and encapsulation
                efficiencies for the antimalarial compounds chloroquine,
                primaquine and quinacrine ranging from 30% to 60% have been
                determined for both carriers. The resulting drug-loaded
                nanocarriers have been tested for their capacity to inhibit
                Plasmodium growth in in vitro and in vivo assays.

# metadata.dc.rights[].value
cc by (c) Royal Society of Chemistry, 2019

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Micelle carriers based on dendritic macromolecules containing
                bis-MPA and glycine for antimalarial drug delivery