# name
Malaria preventive therapy in pregnancy and its potential impact
                on immunity to malaria in an area of declining transmission

# metadata.dc.description.abstract[].value
BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar
                of malaria control, may affect malaria immunity, with
                therapeutic implications in regions of reducing transmission.
                METHODS: Plasma antibodies to leading vaccine candidate
                merozoite antigens and opsonizing antibodies to
                endothelial-binding and placental-binding infected erythrocytes
                were quantified in pregnant Melanesian women receiving
                sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or
                three courses of SP with azithromycin. RESULTS: Malaria
                prevalence was low. Between enrolment and delivery, antibodies
                to recombinant antigens declined in both groups (p < 0.0001).
                In contrast, median levels of opsonizing antibodies did not
                change, although levels for some individuals changed
                significantly. In multivariate analysis, the malaria prevention
                regimen did not influence antibody levels. CONCLUSION: Different
                preventive anti-malarial chemotherapy regimens used during
                pregnancy had limited impact on malarial-immunity in a
                low-transmission region of Papua New Guinea. TRIAL
                REGISTRATIONS: NCT01136850.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1186/s12936-015-0736-x

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Malaria preventive therapy in pregnancy and its potential impact
                on immunity to malaria in an area of declining transmission