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Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

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Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF

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JACC: Basic to Translational Science, 2023, vol. 8, num. 1, p. 1-15

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Articles publicats en revistes (Patologia i Terapèutica Experimental)

# metadata.dc.title[].value
Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes