# name
Electric field causes volumetric changes in the human brain

# metadata.dc.description.abstract[].value
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy
(ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure
activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with
depression to determine the regional relationships between EF, unbiased longitudinal volume
change, and antidepressant response across 85 brain regions. The majority of regional volumes
increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df =
83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study
site), we identified two regions (left amygdala and left hippocampus) with a strong relationship
between EF and volume change (FDR corrected p<0.01). However, neither structural volume
changes nor electric field was associated with antidepressant response. In summary, we showed
that high electrical fields are strongly associated with robust volume changes in a dose-dependent
fashion.

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Electric field causes volumetric changes in the human brain