# name
Maternal HIV infection is an important health determinant in
                non-HIV-infected infants

# metadata.dc.description.abstract[].value
OBJECTIVE: To assess morbidity and mortality in HIV-exposed
                uninfected (HEU) children to help guiding appropriate clinical
                care and effective preventive interventions. DESIGN: This is a
                longitudinal study comparing two cohorts of children; one born
                to HIV-infected women and the other born to HIV-uninfected
                women. METHODS: We have analyzed prospectively obtained
                information on nutritional status, morbidity and mortality from
                966 HEU and 909 HIV-unexposed infants followed up until their
                first 18 months of life at a referral health facility in
                southern Mozambique. Determinants for adverse health outcomes in
                HEU children were also assessed using multivariate logistic
                regression. RESULTS: Increased incidence of hospital admissions
                (P = 0.0015), shorter survival in the first 18 months of life (P
                = 0.0510) and moderate and severe malnutrition (P = 0.0006 and
                0.0014, respectively) were observed among HEU children compared
                with HIV-unexposed children. Incidence of outpatient attendance
                in HEU children was associated with being men, older age and the
                mother being on antiretroviral treatment. Among HEU children,
                those who were never breastfed, or who were weaned or were
                partially breastfed, had an increased incidence of hospital
                admissions compared with children who were exclusively
                breastfed. CONCLUSION: Maternal HIV infection has important
                health consequences in non-HIV-infected children. As the
                prevalence of HIV-infected pregnant women is maintained and the
                proportion of HIV-infected children declines because of the
                scale-up of antiretroviral treatment during pregnancy and
                breastfeeding, more focus should be given to the health needs of
                HEU children to ensure that the post-2015 sustainable
                development goals are met.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1097/QAD.0000000000001499

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Maternal HIV infection is an important health determinant in
                non-HIV-infected infants