# name
Stillbirth With Group B Streptococcus Disease Worldwide:
                Systematic Review and Meta-analyses

# metadata.dc.description.abstract[].value
Background: There are an estimated 2.6 million stillbirths each
                year, many of which are due to infections, especially in low-
                and middle-income contexts. This paper, the eighth in a series
                on the burden of group B streptococcal (GBS) disease, aims to
                estimate the percentage of stillbirths associated with GBS
                disease. Methods: We conducted systematic literature reviews
                (PubMed/Medline, Embase, Literatura Latino-Americana e do Caribe
                em Ciencias da Saude, World Health Organization Library
                Information System, and Scopus) and sought unpublished data from
                investigator groups. Studies were included if they reported
                original data on stillbirths (predominantly >/=28 weeks'
                gestation or >/=1000 g, with GBS isolated from a sterile
                site) as a percentage of total stillbirths. We did meta-analyses
                to derive pooled estimates of the percentage of GBS-associated
                stillbirths, regionally and worldwide for recent datasets.
                Results: We included 14 studies from any period, 5 with recent
                data (after 2000). There were no data from Asia. We estimated
                that 1% (95% confidence interval [CI], 0-2%) of all stillbirths
                in developed countries and 4% (95% CI, 2%-6%) in Africa were
                associated with GBS. Conclusions: GBS is likely an important
                cause of stillbirth, especially in Africa. However, data are
                limited in terms of geographic spread, with no data from Asia,
                and cases worldwide are probably underestimated due to
                incomplete case ascertainment. More data, using standardized,
                systematic methods, are critical, particularly from low- and
                middle-income contexts where the highest burden of stillbirths
                occurs. These data are essential to inform interventions, such
                as maternal GBS vaccination.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1093/cid/cix585

# metadata.dc.relation.ispartof[].value
Clinical Infectious Diseases, 2017, vol. 65, num. suppl_2, p.
                S125-S132

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Stillbirth With Group B Streptococcus Disease Worldwide:
                Systematic Review and Meta-analyses