# name
Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs

# metadata.dc.description.abstract[].value
Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular
infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or the
need of suppressive treatment. Results: Cases (n = 51; 59% women, mean age of 65 years) included
osteoarthritis (n = 27, 53%), prosthetic joint infection (n = 17, 33.3%), and diabetic foot infections (n = 9,
18%); where, 59% were orthopedic device-related. Most frequent isolates were Staphylococcus spp.
(65%, n = 47; S. aureus, 48%). Reasons for choosing tedizolid were potential drug-drug interaction
(63%) and cytopenia (55%); median treatment duration was 29 days (interquartile range -IQR- 15–44),
24% received rifampicin (600 mg once daily) concomitantly, and adverse events were scarce (n = 3).
Hemoglobin and platelet count stayed stable throughout treatment (from 108.6 g/L to 116.3 g/L,
p = 0.079; and 240 × 109/L to 239 × 109/L, p = 0.942, respectively), also in the subgroup of cases with
cytopenia. Among device-related infections, 33% were managed with implant retention. Median
follow-up was 630 days and overall cure rate 83%; among failures (n = 8), 63% were device-related
infections. Conclusions: Long-term use of tedizolid was effective, showing a better safety profile with
less myelotoxicity and lower drug-drug interaction than linezolid. Confirmation of these advantages
could make tedizolid the oxazolidinone of choice for most of osteoarticular infections.

# metadata.dc.rights[].value
cc by (c) Benavent Palomares et al., 2021

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs