# name
Transforming growth factor -α expression in rat experimental hepatocarcinogenesis

# metadata.dc.description.abstract[].value
Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.

# metadata.dc.relation.ispartof[].value
Histology and Histopathology, 1992, vol. 7, num. 3, p. 457-462

# metadata.dc.rights[].value
cc-by-nc-nd (c) Universidad de Murcia, 1992

# metadata.dc.source[].value
Articles publicats en revistes (Patologia i Terapèutica Experimental)

# metadata.dc.title[].value
Transforming growth factor -α expression in rat experimental hepatocarcinogenesis