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Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology

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Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation.

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Frontiers in Immunology, 2016, vol. 3, p. 1-8

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology