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In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates

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Tuberculosis (TB) remains a major threat to human health
                worldwide. The increasing incidence of non-tuberculous
                mycobacterial infections and particularly those produced by
                Mycobacterium avium has emphasized the need to develop new
                drugs. Additionally, high levels of natural drug resistance in
                non-tuberculous mycobacteria (NTM) and the emergence of
                multidrug-resistant (MDR) TB is of great concern. Antimicrobial
                peptides (AMPs) are antibiotics with broad-spectrum
                antimicrobial activity. The objective was to assess the activity
                of AMPs against Mycobacterium tuberculosis and M. avium clinical
                isolates. MICs were determined using microtitre plates and the
                resazurin assay. Mastoparan and melittin showed the greatest
                activity against M. tuberculosis, while indolicidin had the
                lowest MIC against M. avium. In conclusion, AMPs could be
                alternatives for the treatment of mycobacterial infections.
                Further investigation of AMPs' activity in combination and
                associated with conventional antibiotics and their loading into
                drug-delivery systems could lead to their use in clinical
                practice.

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Versió postprint del document publicat a: http://dx.doi.org/
                10.1099/jmm.0.000912

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Journal of Medical Microbiology, 2019, vol. 68, num. 2

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Articles publicats en revistes (Fonaments Clínics)

# metadata.dc.title[].value
In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates