# name
The association between naturally acquired IgG subclass specific
                antibodies to the PfRH5 invasion complex and protection from
                Plasmodium falciparum malaria

# metadata.dc.description.abstract[].value
Understanding the targets and mechanisms of human immunity to
                malaria is important for advancing the development of highly
                efficacious vaccines and serological tools for malaria
                surveillance. The PfRH5 and PfRipr proteins form a complex on
                the surface of P. falciparum merozoites that is essential for
                invasion of erythrocytes and are vaccine candidates. We
                determined IgG subclass responses to these proteins among
                malaria-exposed individuals in Papua New Guinea and their
                association with protection from malaria in a longitudinal
                cohort of children. Cytophilic subclasses, IgG1 and IgG3, were
                predominant with limited IgG2 and IgG4, and IgG
                subclass-specific responses were higher in older children and
                those with active infection. High IgG3 to PfRH5 and PfRipr were
                significantly and strongly associated with reduced risk of
                malaria after adjusting for potential confounding factors,
                whereas associations for IgG1 responses were generally weaker
                and not statistically significant. Results further indicated
                that malaria exposure leads to the co-acquisition of IgG1 and
                IgG3 to PfRH5 and PfRipr, as well as to other PfRH invasion
                ligands, PfRH2 and PfRH4. These findings suggest that IgG3
                responses to PfRH5 and PfRipr may play a significant role in
                mediating naturally-acquired immunity and support their
                potential as vaccine candidates and their use as antibody
                biomarkers of immunity.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1038/srep33094

# metadata.dc.relation.ispartof[].value
Scientific Reports, 2016, vol. 6, num. 33094

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
The association between naturally acquired IgG subclass specific
                antibodies to the PfRH5 invasion complex and protection from
                Plasmodium falciparum malaria