# name
Pulmonary hypertension in chronic obstructive pulmonary disease

# metadata.dc.description.abstract[].value
Even mild pulmonary hypertension (PH) is associated with increased mortality and morbidity in patients with chronic obstructive pulmonary disease (COPD). However, the underlying mechanisms remain elusive; therefore, specific and efficient treatment options are not available. Therapeutic approaches tested in the clinical setting, including long-term oxygen administration and systemic vasodilators, gave disappointing results and might be only beneficial for specific subgroups of patients. Preclinical studies identified several therapeutic approaches for the treatment of PH in COPD. Further research should provide deeper insight into the complex pathophysiological mechanisms driving vascular alterations in COPD, especially as such vascular (molecular) alterations have been previously suggested to affect COPD development. This review summarizes the current understanding of the pathophysiology of PH in COPD and gives an overview of the available treatment options and recent advances in preclinical studies.

# metadata.dc.relation.ispartof[].value
British Journal of Pharmacology, 2019, vol. 178, num. 1, p. 132-151

# metadata.dc.rights[].value
cc-by (c) The British Pharmacological Society, 2019

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
Pulmonary hypertension in chronic obstructive pulmonary disease