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Chapter One – Larock Reaction in the synthesis of heterocyclic compounds

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The indole ring is one of the most common features in natural products and small molecules with important bioactivity. Larock reported a new methodology for the synthesis of the indole ring system based on the palladium-catalyzed heteroannulation of 2-iodoaniline and substituted alkyne moieties. This procedure was subsequently extended to the preparation of other nitrogen- and oxygen- containing heterocycles. This is the process of choice for the synthesis of a large number of heterocyclic derivatives, as it provides outstanding regioselectivity and good to excellent yields.

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Advances in Heterocyclic Chemistry, 2015, vol. 116, p. 1-35

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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Chapter One – Larock Reaction in the synthesis of heterocyclic compounds