# name
Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study

# metadata.dc.description.abstract[].value
BACKGROUND: Evidence for a protective role of physical activity
                against development of stomach cancer is yet inconclusive. We
                studied the association of domain-specific physical activity and
                the risk of gastric adenocarcinoma (GAC), by site and histology,
                in the MCC-Spain case-control study. METHODS: 428 histologically
                confirmed GAC cases (67% men) including the gastro-esophageal
                region and 3225 controls were included. Cases were recruited in
                hospitals from 10 different Spanish regions, whereas population
                controls were randomly selected within the respective hospitals'
                catchment areas. A physical activity (PA) questionnaire was used
                to gather information on household and recreational activities,
                allowing estimation of PA volume (in metabolic equivalents
                (MET)-min/week). Participants also reported the intensity of
                working PA and daily sitting time. Questionnaire data on diet,
                lifestyles and clinical variables including Helicobacter pylori
                serology were available. Adjusted odds ratios (OR) of GAC were
                estimated for domains of physical activity, stratifying by sex,
                site (cardia vs. non-cardia), and Lauren classification
                (intestinal vs. diffuse). RESULTS: Household physical activity
                (HPA) showed a strong inverse association with GAC, observed for
                both cardia and non-cardia tumours. Risk of overall gastric
                cancer was 50% lower risk among participants in the highest HPA
                category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical
                activity (RPA) was also associated with lower overall GAC risk
                (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels
                of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79).
                The protective effect of RPA was strongest for non-cardia
                tumours. Sedentary time was not related to GAC risk (p-trend =
                0.392), but the potential protective effect of RPA was
                restricted to non-sedentary participants. CONCLUSIONS: Both
                household and recreational physical activities were
                independently related to lower GAC risk in the MCC-Spain study.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:               http://dx.doi.org/10.1371/journal.pone.0179731

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study