# name
Risk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach

# metadata.dc.description[].value
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042

# metadata.dc.description.abstract[].value
Triclabendazole (TCBZ) is a veterinary drug used against Fasciola hepatica in cattle. The Cajamarca Valley in Peru is an endemic area of fascioliasis with a high infection rate in animals producing milk for human consumption. The administration of TCBZ during the lactating period can lead to TCBZ derivative residues in milk and cheese entering the human food chain. Milk-derivatives from treated animals have been found positive for TCBZ metabolites. One of these metabolites, triclabendazole sulfoxide
(TCBZSO), is embryolethal during early developmental stages in vitro in mouse
and zebrafish. In this study, we have calculated the estimated daily intake (EDI) of
TCBZSO due to milk and cheese consumption among a rural population in
Cajamarca in order to evaluate the associated risk for human embryonic
development. Although the expected maximum plasma concentration of TCBZSO
after a worst-case scenario simulation would be below the reported lowest
observed adverse effect concentration (LOAEC) for embryolethality in vitro
(10 μM), several limitations on the available information for exposure,
bioavailability and interspecies differences still impede the accomplishment of an
accurate risk assessment.

# metadata.dc.relation.ispartof[].value
Recent Advances in Pharmaceutical Sciences VI, 2016, Research Signpost. Editors: Diego Muñoz Torrero, Àngela Domínguez García & Ma. Ángeles Manresa Presas. ISBN: 978-81-308-0566-5. Chapter 3, p. 37-47.

# metadata.dc.source[].value
Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
Risk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach