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Inhibitors of the M2 channel of influenza A virus

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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392

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Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.

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Reproducció del capítol 2 del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=106

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Recent Advances in Pharmaceutical Sciences, 2011, Chapter 2, p. 35-64. Editor: Diego Muñoz-Torrero

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Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
Inhibitors of the M2 channel of influenza A virus