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Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

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Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different size and complexity. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines.

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Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells