# name
Zika virus infection in pregnancy: a systematic review of
                disease course and complications

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OBJECTIVES: To characterize maternal Zika virus (ZIKV) infection
                and complement the evidence base for the WHO interim guidance on
                pregnancy management in the context of ZIKV infection. METHODS:
                We searched the relevant database from inception until March
                2016. Two review authors independently screened and assessed
                full texts of eligible reports and extracted data from relevant
                studies. The quality of studies was assessed using the
                Newcastle-Ottawa Scale (NOS) and the National Institute of
                Health (NIH) tool for observational studies and case
                series/reports, respectively. RESULTS: Among 142 eligible
                full-text articles, 18 met the inclusion criteria (13 case
                series/reports and five cohort studies). Common symptoms among
                pregnant women with suspected/confirmed ZIKV infection were
                fever, rash, and arthralgia. One case of Guillain-Barre syndrome
                was reported among ZIKV-infected mothers, no other case of
                severe maternal morbidity or mortality reported. Complications
                reported in association with maternal ZIKV infection included a
                broad range of fetal and newborn neurological and ocular
                abnormalities; fetal growth restriction, stillbirth, and
                perinatal death. Microcephaly was the primary neurological
                complication reported in eight studies, with an incidence of
                about 1% among newborns of ZIKV infected women in one study.
                CONCLUSION: Given the extensive and variable fetal and newborn
                presentations/complications associated with prenatal ZIKV
                infection, and the dearth of information provided, knowledge
                gaps are evident. Further research and comprehensive reporting
                may provide a better understanding of ZIKV infection in
                pregnancy and attendant maternal/fetal complications. This
                knowledge could inform the creation of effective and
                evidence-based strategies, guidelines and recommendations aimed
                at the management of maternal ZIKV infection. Adherence to
                current best practice guidelines for prenatal care among health
                providers is encouraged, in the context of maternal ZIKV
                infection.

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Reproductive Health, 2017, vol. 14, num. 28

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Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Zika virus infection in pregnancy: a systematic review of
                disease course and complications