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STAT3 and REDD1: an unconventional story of gene repression

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The non-canonical functions of the transcription factor STAT3 have been poorly studied in comparison to its canonical mechanisms of gene expression activation. Here, Köhler et al. put the spotlight on a novel unconventional repressing mechanism of STAT3 over the REDD1 gene, named DDIT4. These findings are crucial to expand the knowledge of the stress-induced short-lived REDD1 protein that inactivates mTOR and the consequences of this fine-tuned regulation in the context of pathological conditions such as cancer or neurodegenerative diseases.

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cc by (c) García Segura, Pol et al., 2023

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Articles publicats en revistes (Biomedicina)

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STAT3 and REDD1: an unconventional story of gene repression