# name
Physical exercise impact on aging-related pathways across generations in C. elegans

# metadata.dc.description[].value
Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 2023. Tutor/a: Christian Griñán Ferré

# metadata.dc.description.abstract[].value
Aging has been defined as a gradual functional decline with a progressive physiological
integrity loss, increasing the organism’s vulnerability to death. Otherwise, this described
deterioration is the major risk factor for most current human pathologies, including
neurodegenerative diseases, cancer, cardiovascular disorders, and diabetes. However, in the
last decades, non-pharmacological treatments like physical exercise have provided general
health benefits against aging decline. In this study, we aim to analyze how lifestyle factors
such as physical exercise can modify the molecular expression of aging-related pathways and
observe if this gene expression modification pattern is inherited transgenerationally
throughout the following generations.
Among all hallmarks of aging process, in this study we highlight epigenetic alterations. Even
though extensive studies of transgenerational epigenetic inheritance have been reported
in Caenorhabditis elegans, there is still a gap regarding how physical exercise might benefit
organisms through epigenetic pathways. Then, we implement a physical exercise treatment
in the first C. elegans generation, and we analyze the subsequent generations to study
transgenerational heritable changes in gene expression involved in aging-related
pathways. We emphasized on CREB transcription factor pathway, early growth response 1
(EGR1) transcription factor, superoxide dismutase 1 (Sod1) as a powerful antioxidant, and
disintegrin and metalloproteinase domain-containing protein (ADAM10) pathway since its
role in correct neurological development.
Key words: exercise, C. elegans, aging, transgenerational epigenetic

# metadata.dc.rights[].value
cc-by-nc-nd (c) Marta Ribalta Vilella, 2023

# metadata.dc.source[].value
Treballs Finals de Grau (TFG) - Farmàcia

# metadata.dc.title[].value
Physical exercise impact on aging-related pathways across generations in C. elegans