# name
Maternal and fetal genetic contribution to gestational weight
                gain

# metadata.dc.description.abstract[].value
BACKGROUND: Clinical recommendations to limit gestational weight
                gain (GWG) imply high GWG is causally related to adverse
                outcomes in mother or offspring, but GWG is the sum of several
                inter-related complex phenotypes (maternal fat deposition and
                vascular expansion, placenta, amniotic fluid and fetal growth).
                Understanding the genetic contribution to GWG could help clarify
                the potential effect of its different components on maternal and
                offspring health. Here we explore the genetic contribution to
                total, early and late GWG. PARTICIPANTS AND METHODS: A
                genome-wide association study was used to identify maternal and
                fetal variants contributing to GWG in up to 10 543 mothers and
                16 317 offspring of European origin, with replication in 10 660
                mothers and 7561 offspring. Additional analyses determined the
                proportion of variability in GWG from maternal and fetal common
                genetic variants and the overlap of established genome-wide
                significant variants for phenotypes relevant to GWG (e.g.
                maternal BMI and glucose, birthweight). RESULTS: Approximately
                20% of the variability in GWG was tagged by common maternal
                genetic variants, and the fetal genome made a surprisingly minor
                contribution to explaining variation in GWG. Variants near the
                Pregnancy Specific Beta-1-Glycoprotein 5 (PSG5) gene reached
                genome-wide significance (P=1.71 x 10-8) for total GWG in the
                offspring genome, but did not replicate. Some established
                variants associated with increased BMI, fasting glucose and type
                2 diabetes were associated with lower early, and higher later
                GWG. Maternal variants related to higher systolic blood pressure
                were related to lower late GWG. Established maternal and fetal
                birthweight variants were largely unrelated to GWG. CONCLUSION:
                We found a modest contribution of maternal common variants to
                GWG and some overlap of maternal BMI, glucose and type 2
                diabetes variants with GWG. These findings suggest that
                associations between GWG and later offspring/maternal outcomes
                may be due to the relationship of maternal BMI and diabetes with
                GWG.International Journal of Obesity accepted article preview
                online, 09 October 2017. doi:10.1038/ijo.2017.248.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1038/ijo.2017.248

# metadata.dc.relation.ispartof[].value
International Journal of Obesity, 2017, vol. , num. , p. Ahead
                of print

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Maternal and fetal genetic contribution to gestational weight
                gain