# name
Mass testing and treatment for malaria followed by weekly fever
                screening, testing and treatment in Northern Senegal:
                feasibility, cost and impact.

# metadata.dc.description.abstract[].value
BACKGROUND NlmCategory: BACKGROUND content:
Population-wide interventions using malaria testing and
treatment might decrease the reservoir of Plasmodium falciparum
infection and accelerate towards elimination. Questions remain
                about their effectiveness and evidence from different
                transmission settings is needed. - Label: METHODS NlmCategory:
                METHODS content: "A pilot quasi-experimental study to evaluate a
                package of population-wide test and treat interventions was
                conducted in six health facility catchment areas (HFCA) in the
                districts of Kanel, Lingu\xC3\xA8re, and Ran\xC3\xA9rou
                (Senegal). Seven adjacent HFCAs were selected as comparison.
                Villages within the intervention HFCAs were stratified according
                to the 2013 incidences of passively detected malaria cases, and
                those with an incidence\xE2\x80\x89\xE2\x89\xA5\xE2\x80\x8915
                cases/1000/year were targeted for a mass test and treat (MTAT)
                in September 2014. All households were visited, all consenting
                individuals were tested with a rapid diagnostic test (RDT), and,
                if positive, treated with dihydroartemisinin-piperaquine. This
                was followed by weekly screening, testing and treatment of fever
                cases (PECADOM++) until the end of the transmission season in
                January 2015. Villages with lower incidence received only
                PECADOM++ or case investigation. To evaluate the impact of the
                interventions over that transmission season, the incidence of
                passively detected, RDT-confirmed malaria cases was compared
                between the intervention and comparison groups with a
                difference-in-difference analysis using negative binomial
                regression with random effects on HFCA." - Label: RESULTS
                NlmCategory: RESULTS content: "During MTAT, 89% (2225/2503) of
                households were visited and 86% (18,992/22,170) of individuals
                were tested, for a combined 77% effective coverage. Among those
                tested, 291 (1.5%) were RDT positive (range 0-10.8 by village),
                of whom 82% were\xE2\x80\x89<\xE2\x80\x8920\xC2\xA0years old
                and 70% were afebrile. During the PECADOM++ 40,002 visits were
                conducted to find 2784 individuals reporting fever, with an RDT
                positivity of 6.5% (170/2612). The combination of interventions
                resulted in an estimated 38% larger decrease in malaria case
                incidence in the intervention compared to the comparison group
                (adjusted incidence risk ratio\xE2\x80\x89=\xE2\x80\x890.62, 95%
                CI 0.45-0.84, p\xE2\x80\x89=\xE2\x80\x890.002). The cost of the
                MTAT was $14.3 per person." - Label: CONCLUSIONS NlmCategory:
                CONCLUSIONS content: It was operationally feasible to conduct
                MTAT and PECADOM++ with high coverage, although PECADOM++ was
                not an efficient strategy to complement MTAT. The modest impact
                of the intervention package suggests a need for alternative or
                complementary strategies.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Mass testing and treatment for malaria followed by weekly fever
                screening, testing and treatment in Northern Senegal:
                feasibility, cost and impact.