# name
Virulence and Antimicrobial Resistance in Campylobacter spp.
                from a Peruvian Pediatric Cohort

# metadata.dc.description.abstract[].value
The presence of virulence factors (VFs) and mechanisms of
                quinolones and macrolide resistance was analyzed in
                Campylobacter spp. from a pediatric cohort study in Lima. In 149
                isolates (39 Campylobacter jejuni and 24 Campylobacter coli from
                diarrheic cases; 57 C. jejuni and 29 C. coli from controls), the
                presence of the cdtABC and cadF genes and iam marker was
                established. Nalidixic acid, ciprofloxacin, erythromycin, and
                azithromycin susceptibilities were established in 115 isolates
                and tetracycline-susceptibility was established in 100 isolates.
                The presence of mutations in the gyrA, parC, and 23S rRNA genes
                was determined. The cadF gene and all genes from the cdtABC
                operon were significantly more frequent among C. jejuni (P <
                0.0001); the iam marker was more frequent in C. coli (P <
                0.0001). No differences were observed in VFs between cases and
                controls. Almost all isolates were tetracycline-resistant;
                nalidixic acid and ciprofloxacin resistance reached levels of
                90.4% and 88.7%, respectively. Resistance to macrolides was 13%
                (C. jejuni 4.3%; C. coli 26.1%). Resistance to ciprofloxacin was
                related to GyrA Thr86 substitutions, while 13 of 15
                macrolide-resistant isolates possessed a 23S rRNA mutation
                (A2075G). Differences in the presence of VFs and alarming levels
                of resistance to tested antimicrobial agents were observed among
                C. jejuni and C. coli.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1155/2017/7848926

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Virulence and Antimicrobial Resistance in Campylobacter spp.
                from a Peruvian Pediatric Cohort