# name
Cord Blood IL-12 Confers Protection to Clinical Malaria in
                Early Childhood Life

# metadata.dc.description.abstract[].value
Using a well-designed longitudinal cohort, we aimed to identify
                cytokines that were protective against malaria and to explore
                how they were influenced by genetic and immunological factors.
                349 Mozambican pregnant women and their newborn babies were
                recruited and followed up for malaria outcomes until 24 months
                of age. Six Th1 cytokines in cord blood were screened for
                correlation with malaria incidence, of which IL-12 was selected
                for further analyses. We genotyped IL-12 polymorphisms in
                children/mothers and evaluated the genotype-phenotype
                associations and genetic effects on IL-12 levels. Maternal IL-12
                concentrations were also investigated in relation to Plasmodium
                infections and cord blood IL-12 levels. Our data showed that
                high background IL-12 levels were prospectively associated with
                a low incidence of clinical malaria, while IL-12 production
                after parasite stimulation had the opposite effect on malaria
                incidence. IL-12 genotypes (IL-12b rs2288831/rs17860508) and the
                haplotype CGTTAGAG distribution were related to malaria
                susceptibility and background IL-12 levels. Maternal genotypes
                also exhibited an evident impact on host genotype-phenotype
                associations. Finally, a positive correlation in background
                IL-12 levels between maternal and cord blood was identified.
                Thus, cord blood background IL-12 concentrations are important
                for protecting children from clinical malaria, likely mediated
                by both genotypes (children&mothers) and maternal immunity.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Cord Blood IL-12 Confers Protection to Clinical Malaria in
                Early Childhood Life