# name
Dietary Restriction: Standing Up For Sirtuins

# metadata.dc.description.abstract[].value
We believe that L. Fontana, L. Partridge, and V. D. Longo should have included a
discussion of sirtuins in their Review “Extending healthy life span—From yeast to humans”
(16 April, p. 321). We also believe that some of the references used are misleading.
The authors state that the purpose of their Review is to “consider the role of nutrient-sensing
signaling pathways in mediating the beneficial effects of dietary restriction.” Yet there was
no mention of the sirtuins, a family of critically important nutrient-sensing proteins that
promote health span from yeast to mammals, as shown by more than 1000 peer-reviewed
publications from labs around the world. The authors state that “[i]t is unlikely that a single,
linear pathway mediates the effects of dietary restriction in any organism,” and we agree.
Indeed, the aging field now recognizes that healthy life span is under the influence of several
nutrient-sensing pathways, and there is at least as much evidence for the involvement of
sirtuins in the dietary restriction response as for any of the pathways discussed in the Review.

# metadata.dc.publisher[].value
American Association for the Advancement of Science

# metadata.dc.rights[].value
(c) American Association for the Advancement of Science, 2010

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Dietary Restriction: Standing Up For Sirtuins