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Functional Connectivity Analysis of Stem Cell Cultures with Parkinson’s Disease

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Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2021, Tutor: Jordi Soriano Fradera

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We studied the activity and functional network characteristics of neurons derived from human induced pluripotent stem cells (iPSCs) grown in culture. The cells were obtained from healthy and Parkinson’s–aﬀected patients. Using a network perspective, diﬀerent magnitudes were analyzed to demonstrate connectivity and activity diﬀerences between healthy controls, diseased Parkinson’s cultures, and genetically cured ones. We unveiled an excess of integration and a loss of both modularity and small–worldness for Parkinson’s diseased cultures. The study may help the medical society to better understand the disease and develop eﬃcient therapies

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Functional Connectivity Analysis of Stem Cell Cultures with Parkinson’s Disease