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Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

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Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al.©2019 American Association for Cancer Research.

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American Association for Cancer Research

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(c) American Association for Cancer Research, 2019

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC