# name
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

# metadata.dc.description.abstract[].value
Pregnant women constitute a promising sentinel group for
                continuous monitoring of malaria transmission. To identify
                antibody signatures of recent Plasmodium falciparum exposure
                during pregnancy, we dissected IgG responses against VAR2CSA,
                the parasite antigen that mediates placental sequestration. We
                used a multiplex peptide-based suspension array in 2,354 samples
                from pregnant women from Mozambique, Benin, Kenya, Gabon,
                Tanzania, and Spain. Two VAR2CSA peptides of limited
                polymorphism were immunogenic and targeted by IgG responses
                readily boosted during infection and with estimated half-lives
                of <2 years. Seroprevalence against these peptides reflected
                declines and rebounds of transmission in southern Mozambique
                during 2004-2012, reduced exposure associated with use of
                preventive measures during pregnancy, and local clusters of
                transmission that were missed by detection of P. falciparum
                infections. These data suggest that VAR2CSA serology can provide
                a useful adjunct for the fine-scale estimation of the malaria
                burden among pregnant women over time and space.

# metadata.dc.publisher[].value
Centers for Disease Control and Prevention

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy