# name
Asymptomatic Plasmodium vivax infections induce robust IgG
                responses to multiple blood-stage proteins in a low-transmission
                region of western Thailand

# metadata.dc.description.abstract[].value
BACKGROUND: Thailand is aiming to eliminate malaria by the year
                2024. Plasmodium vivax has now become the dominant species
                causing malaria within the country, and a high proportion of
                infections are asymptomatic. A better understanding of antibody
                dynamics to P. vivax antigens in a low-transmission setting,
                where acquired immune responses are poorly characterized, will
                be pivotal for developing new strategies for elimination, such
                as improved surveillance methods and vaccines. The objective of
                this study was to characterize total IgG antibody levels to 11
                key P. vivax proteins in a village of western Thailand. METHODS:
                Plasma samples from 546 volunteers enrolled in a cross-sectional
                survey conducted in 2012 in Kanchanaburi Province were utilized.
                Total IgG levels to 11 different proteins known or predicted to
                be involved in reticulocyte binding or invasion (ARP, GAMA, P41,
                P12, PVX_081550, and five members of the PvRBP family), as well
                as the leading pre-erythrocytic vaccine candidate (CSP) were
                measured using a multiplexed bead-based assay. Associations
                between IgG levels and infection status, age, and spatial
                location were explored. RESULTS: Individuals from a
                low-transmission region of western Thailand reacted to all 11 P.
                vivax recombinant proteins. Significantly greater IgG levels
                were observed in the presence of a current P. vivax infection,
                despite all infected individuals being asymptomatic. IgG levels
                were also higher in adults (18 years and older) than in
                children. For most of the proteins, higher IgG levels were
                observed in individuals living closer to the Myanmar border and
                further away from local health services. CONCLUSIONS: Robust IgG
                responses were observed to most proteins and IgG levels
                correlated with surrogates of exposure, suggesting these
                antigens may serve as potential biomarkers of exposure,
                immunity, or both.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Asymptomatic Plasmodium vivax infections induce robust IgG
                responses to multiple blood-stage proteins in a low-transmission
                region of western Thailand