# name
Plasmodium vivax Diversity and Population Structure across Four
                Continents

# metadata.dc.description.abstract[].value
Plasmodium vivax is the geographically most widespread human
                malaria parasite. To analyze patterns of microsatellite
                diversity and population structure across countries of different
                transmission intensity, genotyping data from 11 microsatellite
                markers was either generated or compiled from 841 isolates from
                four continents collected in 1999-2008. Diversity was highest in
                South-East Asia (mean allelic richness 10.0-12.8), intermediate
                in the South Pacific (8.1-9.9) Madagascar and Sudan (7.9-8.4),
                and lowest in South America and Central Asia (5.5-7.2). A
                reduced panel of only 3 markers was sufficient to identify
                approx. 90% of all haplotypes in South Pacific, African and
                SE-Asian populations, but only 60-80% in Latin American
                populations, suggesting that typing of 2-6 markers, depending on
                the level of endemicity, is sufficient for epidemiological
                studies. Clustering analysis showed distinct clusters in Peru
                and Brazil, but little sub-structuring was observed within
                Africa, SE-Asia or the South Pacific. Isolates from Uzbekistan
                were exceptional, as a near-clonal parasite population was
                observed that was clearly separated from all other populations
                (FST>0.2). Outside Central Asia FST values were highest
                (0.11-0.16) between South American and all other populations,
                and lowest (0.04-0.07) between populations from South-East Asia
                and the South Pacific. These comparisons between P. vivax
                populations from four continents indicated that not only
                transmission intensity, but also geographical isolation affect
                diversity and population structure. However, the high effective
                population size results in slow changes of these parameters.
                This persistency must be taken into account when assessing the
                impact of control programs on the genetic structure of parasite
                populations.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pntd.0003872

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2015, vol. 9, num. 6, p. e0003872

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Plasmodium vivax Diversity and Population Structure across Four
                Continents