# name
Detection of IgE Reactivity to a Handful of Allergen Molecules
                in Early Childhood Predicts Respiratory Allergy in Adolescence

# metadata.dc.description.abstract[].value
BACKGROUND: Sensitization in early childhood may precede
                respiratory allergy in adolescence. METHODS: IgE reactivity
                against 132 allergen molecules was evaluated using the MeDALL
                microarray in sera obtained from a random sample of 786 children
                at the age of 4, 8 and 16years in a population based birth
                cohort (BAMSE). Symptoms were analyzed by questionnaire at ages
                4, 8 and 16years. Clinically and independent relevant allergen
                molecules accounting for >/=90% of IgE reactivities in
                sensitized individuals and at all time-points were identified as
                risk molecules and used to predict respiratory allergy. The data
                was replicated in the Manchester Asthma and Allergy Study (MAAS)
                birth cohort by studying IgE reactivity with the use of a
                commercial IgE microarray. Sera were obtained from children at
                the ages of 3, 5, 8 and 11years (N=248) and the outcome was
                studied at 11years. FINDINGS: In the BAMSE cohort 4 risk
                molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1
                (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the
                corresponding number of molecules was 5: Der p 1 (dust mite),
                Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1
                (cat). In BAMSE, early IgE reactivity to >/=3 of 4 allergen
                molecules at four years predicted incident and persistent asthma
                and/or rhinitis at 16years (87% and 95%, respectively). The
                corresponding proportions in the MAAS cohort at 16years were
                100% and 100%, respectively, for IgE reactivity to >/=3 of 5
                risk molecules. INTERPRETATIONS: IgE reactivity to a few
                allergen molecules early in life identifies children with a high
                risk of asthma and/or rhinitis at 16years. These findings will
                be of importance for developing preventive strategies for asthma
                and rhinitis in children.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1016/j.ebiom.2017.11.009

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.subject.classification[].value
Malalties de l'aparell respiratori en els infants

# metadata.dc.title[].value
Detection of IgE Reactivity to a Handful of Allergen Molecules
                in Early Childhood Predicts Respiratory Allergy in Adolescence