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Modelling of chemotatic sprouting endothelial cells through and extracellular matrix

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Sprouting angiogenesis is a core biological process critical to vascular
development. Its accurate simulation, relevant to multiple facets of human
health, is of broad, interdisciplinary appeal. This study presents an in-silico
model replicating a microfluidic assay where endothelial cells sprout into a
biomimetic extracellular matrix, specifically, a large-pore, low-concentration
fibrin-based porous hydrogel, influenced by chemotactic factors. We introduce
a novel approach by incorporating the extracellular matrix and chemotactic factor
effects into a unified term using a single parameter, primarily focusing on
modelling sprouting dynamics and morphology. This continuous model
naturally describes chemotactic-induced sprouting with no need for additional
rules. In addition, we extended our base model to account for matrix sensing and
degradation, crucial aspects of angiogenesis. We validate our model via a hybrid
in-silico experimental method, comparing the model predictions with
experimental results derived from the microfluidic setup. Our results
underscore the intricate relationship between the extracellular matrix structure
and angiogenic sprouting, proposing a promising method for predicting the
influence of the extracellular matrix on angiogenesis.

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Frontiers In Bioengineering And Biotechnology, 2023

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Articles publicats en revistes (Física de la Matèria Condensada)

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Modelling of chemotatic sprouting endothelial cells through and extracellular matrix