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Relationship Between Biofilm Formation and Antimicrobial
                Resistance in Gram-Negative Bacteria

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Gram-negative microorganisms are a significant cause of
                infection in both community and nosocomial settings. The
                increase, emergence, and spread of antimicrobial resistance
                among bacteria are the most important health problems worldwide.
                One of the mechanisms of resistance used by bacteria is biofilm
                formation, which is also a mechanism of virulence. This study
                analyzed the possible relationship between antimicrobial
                resistance and biofilm formation among isolates of three
                Gram-negative bacteria species. Several relationships were found
                between the ability to form biofilm and antimicrobial
                resistance, being different for each species. Indeed, gentamicin
                and ceftazidime resistance was related to biofilm formation in
                Escherichia coli, piperacillin/tazobactam, and colistin in
                Klebsiella pneumoniae, and ciprofloxacin in Pseudomonas
                aeruginosa. However, no relationship was observed between global
                resistance or multidrug-resistance and biofilm formation. In
                addition, compared with other reported data, the isolates in the
                present study showed higher rates of antimicrobial resistance.
                In conclusion, the acquisition of specific antimicrobial
                resistance can compromise or enhance biofilm formation in
                several species of Gram-negative bacteria. However,
                multidrug-resistant isolates do not show a trend to being
                greater biofilm producers than non-multiresistant isolates.

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Versió posprint del document publicat a: http://dx.doi.org/
                10.1089/mdr.2018.0027

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Microbial Drug Resistance, 2019 , vol. 25 , num. 1

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Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Relationship Between Biofilm Formation and Antimicrobial
                Resistance in Gram-Negative Bacteria