# name
Host-Based Prognostic Biomarkers to Improve Risk Stratification and Outcome of Febrile Children in Low- and Middle-Income Countries.

# metadata.dc.description.abstract[].value
"Fever is one of the leading causes for pediatric medical consultation and the most common symptom at clinical presentation in low- and middle-income countries (LMICs). Most
                febrile episodes are due to self-limited infections, but a small
                proportion of children will develop life-threatening infections.
                The early recognition of children who have or are progressing to
                a critical illness among all febrile cases is challenging, and
                there are currently no objective and quantitative tools to do
                so. This results in increased morbidity and mortality among
                children with impending life-threatening infections, whilst
                contributing to the unnecessary prescription of antibiotics,
                overwhelming health care facilities, and harm to patients
                receiving avoidable antimicrobial treatment. Specific fever
                origin is difficult to ascertain and co-infections in LMICs are
                common. However, many severe infections share common pathways of
                host injury irrespective of etiology, including immune and
                endothelial activation that contribute to the pathobiology of
                sepsis (i.e., pathogen \"agnostic\" mechanisms of disease).
                Importantly, mediators of these pathways are independent markers
                of disease severity and outcome. We propose that measuring
                circulating levels of these factors can provide quantitative and
                objective evidence to: enable early recognition of severe
                infection; guide patient triage and management; enhance
                post-discharge risk stratification and follow up; and mitigate
                potential gender bias in clinical decisions. Here, we review the
                clinical and biological evidence supporting the clinical utility
                of host immune and endothelial activation biomarkers as
                components of novel rapid triage tests, and discuss the
                challenges and needs for developing and implementing such
                tools."

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Host-Based Prognostic Biomarkers to Improve Risk Stratification and Outcome of Febrile Children in Low- and Middle-Income Countries.