# name
Trends in Transmission of Drug Resistance and Prevalence of
                Non-B Subtypes in Patients with Acute or Recent HIV-1 Infection
                in Barcelona in the Last 16 Years (1997-2012)

# metadata.dc.description.abstract[].value
OBJECTIVES: To evaluate the prevalence of transmitted drug
                resistance (TDR) and non-B subtypes in patients with
                acute/recent HIV-1 infection in Barcelona during the period
                1997-2012. METHODS: Patients from the "Hospital Clinic Primary
                HIV-1 Infection Cohort" with a genotyping test performed within
                180 days of infection were included. The 2009 WHO List of
                Mutations for Surveillance of Transmitted HIV-1 Drug Resistance
                was used for estimating the prevalence of TDR and phylogenetic
                analysis for subtype determination. RESULTS: 189 patients with
                acute/recent HIV-1 infection were analyzed in 4 time periods
                (1997-2000, n=28; 2001-4, n=42; 2005-8, n=55 and 2009-12, n=64).
                The proportion of patients with acute/recent HIV-1 infection
                with respect to the total of newly HIV-diagnosed patients in our
                center increased over the time and was 2.18%, 3.82%, 4.15% and
                4.55% for the 4 periods, respectively (p=0.005). The global
                prevalence of TDR was 9%, or 17.9%, 9.5%, 3.6% and 9.4% by study
                period (p=0.2). The increase in the last period was driven by
                protease-inhibitor and
                nucleoside-reverse-transcriptase-inhibitor resistance mutations
                while non-nucleoside-reverse-transcriptase inhibitor TDR and TDR
                of more than one family decreased. The overall prevalence of
                non-B subtypes was 11.1%, or 0%, 4.8%, 9.1% and 20.3 by study
                period (p=0.01). B/F recombinants, B/G recombinants and subtype
                F emerged in the last period. We also noticed an increase in the
                number of immigrant patients (p=0.052). The proportion of
                men-who-have-sex-with-men (MSM) among patients with acute/recent
                HIV-1 infection increased over the time (p=0.04). CONCLUSIONS:
                The overall prevalence of TDR in patients with acute/recent
                HIV-1 infection in Barcelona was 9%, and it has stayed
                relatively stable in recent years. Non-B subtypes and immigrants
                proportions progressively increased.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0125837

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Trends in Transmission of Drug Resistance and Prevalence of
                Non-B Subtypes in Patients with Acute or Recent HIV-1 Infection
                in Barcelona in the Last 16 Years (1997-2012)