# name
A novel redox cycle diverts cells from oncogene-induced senescence into cancer

# metadata.dc.description.abstract[].value
Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Copyright © 2021 Elsevier Inc. All rights reserved.

# metadata.dc.source[].value
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

# metadata.dc.title[].value
A novel redox cycle diverts cells from oncogene-induced senescence into cancer