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New cationic vesicles prepared with double chain surfactants from arginine: role of the hydrophobic group on the antimicrobial activity and cytotoxicity

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Manresa Presas, Ma. Ángeles (María Ángeles)

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Cationic double chain surfactants have attracted much interest because they can give rise to cationic vesicles that can be used in biomedical applications. Using a simple and economical synthetic approach, we have synthesized four double-chain surfactants with different alkyl chain lengths (LANHCx). The critical aggregation concentration of the double chain surfactants is at least one order of magnitude lower than the CMC of their corresponding single-chain LAM and the solutions prepared with the LANHCx contain stable cationic vesicles. Encouragingly, these new arginine derivatives show very low haemolytic activity and weaker cytotoxic effects than conventional dialkyl dimethyl ammonium surfactants. In addition, the surfactant with the shortest alkyl chain exhibits good antimicrobial activity against Gram-positive bacteria. The results show that a rational design applied to cationic double chain surfactants might serve as a promising strategy for the development of safe cationic vesicular systems.

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Colloids and Surfaces B-Biointerfaces, 2016, vol. 141, p. 19-27

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Articles publicats en revistes (Bioquímica i Fisiologia)

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New cationic vesicles prepared with double chain surfactants from arginine: role of the hydrophobic group on the antimicrobial activity and cytotoxicity