# name
Incidence and risk factors for hypertension among HIV patients
                in rural Tanzania - A prospective cohort study

# metadata.dc.description.abstract[].value
INTRODUCTION: Scarce data are available on the epidemiology of
                hypertension among HIV patients in rural sub-Saharan Africa. We
                explored the prevalence, incidence and risk factors for incident
                hypertension among patients who were enrolled in a rural HIV
                cohort in Tanzania. METHODS: Prospective longitudinal study
                including HIV patients enrolled in the Kilombero and Ulanga
                Antiretroviral Cohort between 2013 and 2015. Non-ART naive
                subjects at baseline and pregnant women during follow-up were
                excluded from the analysis. Incident hypertension was defined as
                systolic blood pressure >/= 140 mmHg and/or diastolic blood
                pressure >/= 90 mmHg on two consecutive visits. Cox
                proportional hazards models were used to assess the association
                of baseline characteristics and incident hypertension. RESULTS:
                Among 955 ART-naive, eligible subjects, 111 (11.6%) were
                hypertensive at recruitment. Ten women were excluded due to
                pregnancy. The remaining 834 individuals contributed 7967
                person-months to follow-up (median 231 days, IQR 119-421) and 80
                (9.6%) of them developed hypertension during a median follow-up
                of 144 days from time of enrolment into the cohort [incidence
                rate 120.0 cases/1000 person-years, 95% confidence interval (CI)
                97.2-150.0]. ART was started in 630 (75.5%) patients, with a
                median follow-up on ART of 7 months (IQR 4-14). Cox regression
                models identified age [adjusted hazard ratio (aHR) 1.34 per 10
                years increase, 95% CI 1.07-1.68, p = 0.010], body mass index
                (aHR per 5 kg/m2 1.45, 95% CI 1.07-1.99, p = 0.018) and
                estimated glomerular filtration rate (aHR < 60 versus >/=
                60 ml/min/1.73 m2 3.79, 95% CI 1.60-8.99, p = 0.003) as
                independent risk factors for hypertension development.
                CONCLUSIONS: The prevalence and incidence of hypertension were
                high in our cohort. Traditional cardiovascular risk factors
                predicted incident hypertension, but no association was observed
                with immunological or ART status. These data support the
                implementation of routine hypertension screening and integrated
                management into HIV programmes in rural sub-Saharan Africa.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0172089

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Incidence and risk factors for hypertension among HIV patients
                in rural Tanzania - A prospective cohort study