# name
Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases

# metadata.dc.description.abstract[].value
There are at least two different etio-pathogenic pathways for
                the development of vulvar squamous cell carcinoma (VSCC): one
                associated with infection by human papillomavirus (HPV) and
                another independent of HPV. We aimed to describe the
                histological characteristics of HPV-associated and
                HPV-independent tumors and to determine the best strategy to
                identify HPV in VSCC. A single paraffin block was available for
                review from a series of 1594 VSCCs. In all cases HPV DNA
                detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and
                p16 immunohistochemistry (IHC). A tumor was considered as
                unquestionably HPV-associated if both HPV DNA and p16 IHC were
                positive. A tumor was considered indisputably HPV-independent if
                both HPV DNA and p16 IHC were negative. Two groups of tumors
                were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV
                DNA-/p16+. WHO typing and a thorough histological evaluation
                were conducted in all cases. 441 tumors were HPV DNA+ with 367
                cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors
                were more frequently basaloid or warty (49.8%), but 36.5% were
                of the keratinizing type. 1153 tumors were HPV DNA-, with 1060
                cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors
                were mostly keratinizing (81.2%) but were occasionally basaloid
                or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were
                similar to those of the HPV-associated VSCC, and HPV DNA+/p16-
                (n=74) cases had a more diverse profile, although they were more
                similar to HPV-independent tumors. Several histological
                characteristics were more frequently associated with HPV-related
                VSCC (koilocytotic-like change, necrosis, moderate to marked
                pleomorphism, invasive front in nests; p<0.001), however,
                none of these characteristics allowed differentiation between
                HPV-associated and -independent VSCC. In conclusion,
                histological criteria do not allow differentiation between
                HPV-associated and -independent VSCC. p16 alone is a clinically
                easy strategy to determine HPV status in VSCC. This article is
                protected by copyright. All rights reserved.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1002/ijc.31006

# metadata.dc.relation.ispartof[].value
International Journal of Cancer, 2017, vol. , num. , p. Ahead of
                print

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases