# name
Empirical and theoretical investigation into the potential
                impacts of insecticide resistance on the effectiveness of
                insecticide-treated bed nets

# metadata.dc.description.abstract[].value
In spite of widespread insecticide resistance in vector
                mosquitoes throughout Africa, there is limited evidence that
                long-lasting insecticidal bed nets (LLINs) are failing to
                protect against malaria. Here, we showed that LLIN contact in
                the course of host-seeking resulted in higher mortality of
                resistant Anopheles spp. mosquitoes than predicted from standard
                laboratory exposures with the same net. We also found that
                sublethal contact with an LLIN caused a reduction in blood
                feeding and subsequent host-seeking success in multiple lines of
                resistant mosquitoes from the laboratory and the field. Using a
                transmission model, we showed that when these LLIN-related
                lethal and sublethal effects were accrued over mosquito
                lifetimes, they greatly reduced the impact of resistance on
                malaria transmission potential under conditions of high net
                coverage. If coverage falls, the epidemiological impact is far
                more pronounced. Similarly, if the intensity of resistance
                intensifies, the loss of malaria control increases nonlinearly.
                Our findings help explain why insecticide resistance has not yet
                led to wide-scale failure of LLINs, but reinforce the call for
                alternative control tools and informed resistance management
                strategies.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1111/eva.12574

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Empirical and theoretical investigation into the potential
                impacts of insecticide resistance on the effectiveness of
                insecticide-treated bed nets