# name
Genes Interacting with Occupational Exposures to Low Molecular
                Weight Agents and Irritants on Adult-Onset Asthma in Three
                European Studies

# metadata.dc.description.abstract[].value
BACKGROUND: The biological mechanisms by which cleaning products
                and disinfectants - an emerging risk factor - affect respiratory
                health remain incompletely evaluated. Studying genes by
                environment interactions (GxE) may help identify new genes
                related to adult-onset asthma. OBJECTIVES: To identify
                interactions between genetic polymorphisms of a large set of
                genes involved in the response to oxidative stress, and
                occupational exposures to low molecular weight (LMW) agents or
                irritants on adult-onset asthma. METHODS: Data came from three
                large European cohorts: EGEA, SAPALDIA, and ECRHS. A candidate
                pathway-based strategy identified 163 genes involved in response
                to oxidative stress and potentially related with exposures to
                LMW agents/irritants. Occupational exposures were evaluated
                using an asthma job-exposure matrix and job-specific
                questionnaires for cleaners and healthcare workers. Logistic
                regression models were used to detect GxE interactions, adjusted
                for age, sex and population ancestry in 2599 adults (Mean age:
                47 years, 60% women, 36% exposed, 18% asthmatics). P-values were
                corrected for multiple comparisons. RESULTS: Ever exposure to
                LMW agents/irritants was associated with current adult-onset
                asthma (OR(95%CI)=1.28(1.04,1.58)). Eight SNP by exposure
                interactions at five loci were found at p<0.005: PLA2G4A
                (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2),
                near RELA (rs931127, rs7949980, chromosome 11), PRKD1
                (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA
                (rs6504453, chromosome 17). Results were consistent across the
                three studies and after accounting for smoking. CONCLUSIONS:
                Using a pathway-based selection process, we identified novel
                genes potentially involved in the adult asthma in relation with
                occupational exposure. These genes play a role in the NF-kB
                pathway involved in inflammation.

# metadata.dc.publisher[].value
National Institute of Environmental Health Sciences

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1289/EHP376

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Genes Interacting with Occupational Exposures to Low Molecular
                Weight Agents and Irritants on Adult-Onset Asthma in Three
                European Studies