# name
malERA: An updated research agenda for insecticide and drug
                resistance in malaria elimination and eradication

# metadata.dc.contributor.author[].value
malERA Refresh Consultative Panel on Insecticide and Drug Resistance

# metadata.dc.description.abstract[].value
Resistance to first-line treatments for Plasmodium falciparum
                malaria and the insecticides used for Anopheles vector control
                are threatening malaria elimination efforts. Suboptimal
                responses to drugs and insecticides are both spreading
                geographically and emerging independently and are being seen at
                increasing intensities. Whilst resistance is unavoidable, its
                effects can be mitigated through resistance management
                practices, such as exposing the parasite or vector to more than
                one selective agent. Resistance contributed to the failure of
                the 20th century Global Malaria Eradication Programme, and yet
                the global response to this issue continues to be slow and
                poorly coordinated-too often, too little, too late. The Malaria
                Eradication Research Agenda (malERA) Refresh process convened a
                panel on resistance of both insecticides and antimalarial drugs.
                This paper outlines developments in the field over the past 5
                years, highlights gaps in knowledge, and proposes a research
                agenda focused on managing resistance. A deeper understanding of
                the complex biological processes involved and how resistance is
                selected is needed, together with evidence of its public health
                impact. Resistance management will require improved use of
                entomological and parasitological data in decision making, and
                optimisation of the useful life of new and existing products
                through careful implementation, combination, and evaluation. A
                proactive, collaborative approach is needed from basic science
                and the development of new tools to programme and policy
                interventions that will ensure that the armamentarium of drugs
                and insecticides is sufficient to deal with the challenges of
                malaria control and its elimination.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pmed.1002450

# metadata.dc.rights[].value
cc by (c) malERA Refresh Consultative Panel on Insecticide and Drug Resistance, 2017

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
malERA: An updated research agenda for insecticide and drug
                resistance in malaria elimination and eradication