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Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds

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A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step.

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Angewandte Chemie-International Edition, 2016, vol. 55, num. 22, p. 6467-6470

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds